![]() ![]() A rapid pericentral inflammatory infiltrate enriched in F4/80 + monocytes co-localized with SMA + myofibroblasts resulted in early collagen deposition, marking the start of an initial fibrotic phase (1 to 6 weeks). Thioacetamide treatment induced two phases of liver fibrosis. To address this issue, liver inflammation, ductular reaction (DR), and fibrosis were induced in C57BL/6 mice by thioacetamide administration for up to 12 weeks. ![]() However, the temporal and mechanistic contributions of these cells to fibrosis are obscure. The interplay between the inflammatory infiltrate and tissue resident cell populations invokes fibrogenesis. ![]()
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